If you're a hardware enthusiast this card isn't really relevant for you, but more than likely there's someone in your family or circle of friends that owns an old PC and would like a little better graphical performance. The ASUS GTX650-E-2GD5 is perfect for systems like that, as it doesn't require a PEG connector and gets all of its power from the PCI-Express bus.
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips