The performance gains to be had from overclocking a GTX 780 are likely dramatic enough to overtake an NVIDIA GeForce GTX Titan and beyond. Frame rates are much improved across the board and in my view, brings the GTX 780 to a whole new performance tier.
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips