If you have hardware that doesnt support 2.5 hard drives and would like to step up to a SSD or one of the new hybrid 2.5 hard drives, you have a few choices. One option is to get a bracket to install the 2.5 drive into a 3.5 drive bay. However, that is often times not a good option, Icy Dock has shown us a better way to convert 2.5 drives into the 3.5 form factor. Using either of their converter enclosures will allow you to use a 2.5 drive in a 3.5 drive bay, a NAS, server, external hard drive enclosure or virtually any device that uses 3.5 hard drives..."
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips