A mini ITX PC Case capable of holding a dual PCI slot graphics card, ATX power supply, full sized optical drive, two 3.5' and two 2.5' drives? If you don't believe it exists then you really need to check the latest PC-Q11 Mini ITX Case by Lian Li.
Slow computer got you down? Maybe a hardware upgrade should be in your cards, if so this guide to the Fundamentals of Upgrading a PC is an invaluable read. PCSTATS Tips