A mini ITX PC Case capable of holding a dual PCI slot graphics card, ATX power supply, full sized optical drive, two 3.5' and two 2.5' drives? If you don't believe it exists then you really need to check the latest PC-Q11 Mini ITX Case by Lian Li.
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips