Very few names in the graphics card industry have the balls to take a GPU and then redesign a completely new infrastructure around it. Amongst them ASUS as they took an Radeon HD 6970 GPU... and did just that. They designed a PCB around it, then used a rather sizable cooler and labeled the product EAH6970 DCII/2DI4S/2GD5.
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips