The Zotac H67-ITX is the most capable mini-ITX board on the market. It offers a full set of features including SATA 6 Gbps, eSATA, USB 3.0, and 802.11n, not to mention full support for Intel's Sandy Bridge processors.
Slow computer got you down? Maybe a hardware upgrade should be in your cards, if so this guide to the Fundamentals of Upgrading a PC is an invaluable read. PCSTATS Tips