The Zotac H67-ITX is the most capable mini-ITX board on the market. It offers a full set of features including SATA 6 Gbps, eSATA, USB 3.0, and 802.11n, not to mention full support for Intel's Sandy Bridge processors.
Any major computer upgrade generally requires a full software reinstall too. No so if you heed the advice in the guide to Upgrading a Motherboard without Reinstalling. PCSTATS Tips