Superman star Christopher Reeve, who lobbied for medical research after being paralysed in a fall nine years ago, has died aged 52.
He had been suffering from an infection as a result of a pressure wound and died on Sunday, his publicist said.
He suffered a cardiac arrest at his New York home and slipped into a coma, Wesley Combs added.
Reeve was paralysed in 1995 when he broke his neck after being thrown from a horse.
He later became an advocate for spinal cord injury research. In recent years, he had regained sensation in some parts of his body.